PHYSICAL MAPPING OF SEQUENCES HOMOLOGOUS TO AN ENDOGENOUS RETROVIRUS LTR ON HUMAN-CHROMOSOME-19

被引:19
作者
LEBEDEV, YB
VOLIK, SV
OBRADOVIC, D
ERMOLAEVA, OD
ASHWORTH, LK
LENNON, GG
SVERDLOV, ED
机构
[1] RUSSIAN ACAD SCI, SHEMYAKIN OVCHINNIKOV INST BIOORGAN CHEM, MOSCOW 117871, RUSSIA
[2] LAWRENCE LIVERMORE NATL LAB, CTR HUMAN GENOME, LIVERMORE, CA 94550 USA
来源
MOLECULAR AND GENERAL GENETICS | 1995年 / 247卷 / 06期
关键词
CHROMOSOME MAPPING; HNCDNA LIBRARY; HUMAN CHROMOSOME 19; SOLITARY LTR; TRANSCRIPTIONAL REGULATION;
D O I
10.1007/BF00290406
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The human genome contains multiple copies of sequences related to the HERV-K family of endogenous retroviruses, homologous to the B-type mouse mammary tumour virus. A DNA fragment closely resembling an HERV-K long tandem repeat (LTR) was detected in a library of hncDNA clones enriched for sequences from human chromosome 19. Sites showing homology to the sequence of this fragment have been identified on human chromosome 19 by hybridization to previously mapped chromosome 19 cosmids. Thus the distribution of LTR sequences on a specific human chromosome has been mapped for the first time. We estimate the total number of such sites on human chromosome 19 to be at least 110. Many of these sites are located in the vicinity of known genes. The precise localizations (to specific cosmids) of LTR-homologous sequences on chromosome 19 can serve as a reference source and will automatically provide further insight into LTR-gene relationships as new genes are mapped onto the chromosome.
引用
收藏
页码:742 / 748
页数:7
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