RETROGRADE-AMNESIA PRODUCED BY INTRASTRIATAL ATROPINE AND ITS REVERSAL BY CHOLINE

被引：13

作者：

SOLANAFIGUEROA, R ^{[1
]}

PRADOALCALA, RA ^{[1
]}

机构：

[1] NATL AUTONOMOUS UNIV MEXICO,FAC MED,DEPT PHYSIOL,POB 70-250,MEXICO CITY,DF,MEXICO

来源：

LIFE SCIENCES | 1990年 / 46卷 / 10期

关键词：

D O I：

10.1016/0024-3205(90)90072-Y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A number of studies have shown that cholinergic blockade of the striatum produces amnesia. In the present experiment it was predicted that by increasing the synthesis of striatal acetylcholine such amnesic state would be prevented. Atropine was injected into the striatum of rats before training of passive avoidance; some of these rats were also injected, intrastriatally, with choline before testing the retention of the task. Atropine alone produced amnesia while the combination of treatments reversed this effect. © 1990.

引用

页码：679 / 686

页数：8

共 24 条

[1] ACETYLCHOLINE METABOLISM IN THE RAT HIPPOCAMPUS AND STRIATUM FOLLOWING ONE-TRIAL PASSIVE TRAINING [J].

BARKER, LA ;

GLICK, SD ;

GREEN, JP ;

KHANDELWAL, J .

NEUROPHARMACOLOGY, 1982, 21 (02) :183-185

[2]

BARRETT EF, 1976, BIOL CHOLINERGIC FUN, P29

[3] IS CHOLINERGIC ACTIVITY OF THE STRIATUM INVOLVED IN THE ACQUISITION OF POSITIVELY-MOTIVATED BEHAVIORS [J].

BERMUDEZRATTONI, F ;

MUJICAGONZALEZ, M ;

PRADOALCALA, RA .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, 24 (03) :715-719

[4] BRAIN ACETYLCHOLINE - INCREASE AFTER SYSTEMIC CHOLINE ADMINISTRATION [J].

COHEN, EL ;

WURTMAN, RJ .

LIFE SCIENCES, 1975, 16 (07) :1095-1102

[5]

DEADWYLER SA, 1972, PHYSIOL BEHAV, V8, P631

[6]

FERNANDEZ SM, 1977, SOC NEUR ABSTR, V3, P232

[7] INCREASE IN RAT-BRAIN ACETYLCHOLINE INDUCED BY CHOLINE OR DEANOL [J].

HAUBRICH, DR ;

WANG, PFL ;

CLODY, DE ;

WEDEKING, PW .

LIFE SCIENCES, 1975, 17 (06) :975-980

[8] ACETYLCHOLINE SYNTHESIS IN RAT-BRAIN - DISSIMILAR EFFECTS OF CLOZAPINE AND CHLORPROMAZINE [J].

HAUBRICH, DR ;

WANG, PFL ;

HERMAN, RL ;

CLODY, DE .

LIFE SCIENCES, 1975, 17 (05) :739-748

[9] RETROGRADE-AMNESIA AND CHOLINERGIC SYSTEMS IN CAUDATE-PUTAMEN COMPLEX AND DORSAL HIPPOCAMPUS OF RAT [J].

HAYCOCK, JW ;

DEADWYLER, SA ;

SIDEROFF, SI ;

MCGAUGH, JL .

EXPERIMENTAL NEUROLOGY, 1973, 41 (01) :201-213

[10]

HULL CHESTER D., 1967, BRAIN TIES, V6, P22, DOI 10.1016/0006-8993(67)90180-1

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