INTERACTION OF 4-HYDROXYNONENAL-MODIFIED LOW-DENSITY LIPOPROTEINS WITH THE FIBROBLAST APOLIPOPROTEIN-B/E RECEPTOR

被引：39

作者：

JESSUP, W

JURGENS, G

LANG, J

ESTERBAUER, H

DEAN, RT

机构：

[1] BRUNEL UNIV, DEPT APPL BIOL, CELL BIOL RES GRP, UXBRIDGE UB8 3PH, MIDDX, ENGLAND

[2] GRAZ UNIV, INST MED BIOCHEM, A-8010 GRAZ, AUSTRIA

[3] GRAZ UNIV, INST BIOCHEM, A-8010 GRAZ, AUSTRIA

来源：

BIOCHEMICAL JOURNAL | 1986年 / 234卷 / 01期

关键词：

D O I：

10.1042/bj2340245

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The incorporation of the lipid peroxidation product 4-hydroxynonenal into low-density lipoprotein (LDL) increases the negative charge of the particle, and decreases its affinity for the fibroblast LDL receptor. It is suggested that this modification may occur in vivo, and might promote atherogenesis.

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页码：245 / 248

页数：4

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