PERFUSION WITH ANTIINSULIN GAMMA-GLOBULIN INDICATES A B TO A TO D CELLULAR PERFUSION SEQUENCE IN THE PANCREAS OF THE RHESUS-MONKEY, MACACA-MULATTA

被引：23

作者：

STAGNER, JI

SAMOLS, E

KOERKER, DJ

GOODNER, CJ

机构：

[1] Research Service, Veterans Administration Medical Center and the Department of Medicine, University of Louisville, Louisville, KY

[2] Department of Medicine, Physiology and Biophysics, and the Regional Primate Research Center, University of Washington, Seattle, WA

来源：

PANCREAS | 1992年 / 7卷 / 01期

关键词：

MONKEY; ISLET CELLS; INTRAISLET; INSULIN; GLUCAGON; SOMATOSTATIN;

D O I：

10.1097/00006676-199201000-00005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The cellular sequence of intraislet vascular perfusion has been shown to be important in the regulation of islet hormone secretion in the rat and dog islet. In order to test whether a B to A to D sequence of islet cellular perfusion is also present in a nonhuman primate, pancreata from the rhesus monkey, Macaca mulatta, were isolated and perfused in vitro in the presence and absence of anti-insulin gamma globulin. In the presence of the insulin antibody, efflux concentration of insulin decreased rapidly (-95 +/- 1.8%), whereas glucagon and somatostatin concentrations increased (111 +/- 28% and 239 +/- 38%, respectively). These results suggest the presence of a B-A-D cellular sequence of vascular perfusion within the monkey islet. The present results also strongly support the hypothesis that a B-A-D sequence of islet perfusion is important in the regulation of islet hormone secretion and further emphasize the central role of the B-cell in intraislet cellular interactions. The results also suggest that, despite differences in islet anatomy, a B-A-D order of islet cellular perfusion may be the preferred functional sequence among mammalian species.

引用

页码：26 / 29

页数：4

共 21 条

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