GENERAL-SYNTHESIS OF POLYFUNCTIONALIZED FLUOROMETHYLENEKETONE RETROAMIDES AS POTENTIAL INHIBITORS OF THROMBIN

被引：50

作者：

ALTENBURGER, JM ^{[1
]}

SCHIRLIN, D ^{[1
]}

机构：

[1] MARION MERRELL DOW RES INST,16 RUE ANKARA,F-67009 STRASBOURG,FRANCE

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 49期

关键词：

D O I：

10.1016/0040-4039(91)80491-N

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of polyfunctionalyzed fluoromethyleneketone retroamides is described. A potential inhibitor of human Thrombin has been prepared through a Reformatsky type condensation from N-protected p.NO2 phenylalaninal. The reaction conditions are applicable to a variety of NO2 substituted aldehydes.

引用

页码：7255 / 7258

页数：4

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