HEMATOCRIT MODIFIES THE CIRCULATORY CONTROL OF SYSTEMIC AND MYOCARDIAL OXYGEN UTILIZATION IN SEPTIC SHEEP

被引：14

作者：

FOX, GA

BERSTEN, A

LAM, C

NEAL, A

RUTLEDGE, FS

INMAN, K

SIBBALD, WJ

机构：

[1] VICTORIAN HOSP CORP,CRIT CARE,LONDON N6A 4G5,ON,CANADA

[2] VICTORIA HOSP,RES INST,AC BURTON VASC BIOL LAB,LONDON N6A 4G5,ON,CANADA

[3] UNIV WESTERN ONTARIO,DEPT MED,PROGRAM CRIT CARE,LONDON,ON,CANADA

[4] UNIV WESTERN ONTARIO,DEPT SURG,PROGRAM CRIT CARE,LONDON N6A 3K7,ON,CANADA

来源：

CRITICAL CARE MEDICINE | 1994年 / 22卷 / 03期

关键词：

SEPSIS; HEMATOCRIT; MYOCARDIAL BLOOD FLOWS; OXYGEN DELIVERY; OXYGEN EXTRACTION; CARDIAC INDEX; ANEMIA; MYOCARDIUM; CRITICAL ILLNESS; HEART;

D O I：

10.1097/00003246-199403000-00018

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Objective: To describe the relationship between hematocrit and oxygen utilization before and after the onset of a hyperdynamic septic state. Design: Prospective, observational study. Setting: Laboratory of a large university-affiliated medical school. Subjects: Thirty mature sheep, each weighing 30 to 40 kg (0.9 to 1.1 m(2) body surface area). Interventions: After baseline measurements, cecal ligation and perforation were used to establish an intra-abdominal source of infection. The abdominal wound was closed and animals were studied on the second postoperative day. An increase in cardiac output of greater than or equal to 30% was used to arbitrarily define the onset of sepsis. Repeat measurements were performed and the animal was killed.

引用

页码：470 / 479

页数：10

共 32 条

[1] SEQUENTIAL CARDIORESPIRATORY PATTERNS ASSOCIATED WITH OUTCOME IN SEPTIC SHOCK [J].