PLATINUM-DIHALIDE COMPLEXES WITH N-ALKYL O-ETHYLTHIOCARBAMATES

被引：15

作者：

FARAGLIA, G ^{[1
]}

SINDELLARI, L ^{[1
]}

CHERCHI, V ^{[1
]}

FURLANI, A ^{[1
]}

PAPAIOANNOU, A ^{[1
]}

SCARCIA, V ^{[1
]}

机构：

[1] UNIV TRIESTE,IST FARMACOL & FARMACOGNOSIA,I-34127 TRIESTE,ITALY

来源：

TRANSITION METAL CHEMISTRY | 1993年 / 18卷 / 01期

关键词：

D O I：

10.1007/BF00136048

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The thiocarbamic esters (L)ETC(EtOSCNHEt)and PTC (EtOSCNHPr) act as sulphur donors towards platinum halides, yielding the cis-[Pt(L)2Cl2], trans-[Pt(L)2Br2], [Pt(L)3X]X (X = Cl or Br) and [Pt(L)4]X2 (X = Cl, Br or I) complexes. By addition of n-hexane to platinum chloride solutions in pure ligands the 1:6 adducts [Pt(L)4]Cl2 . 2L have been isolated. The non-bonded ligand molecules are easily' released to give the corresponding 1:4 complexes. The compounds have been characterized by elemental analysis and spectroscopy. The 1:4 and 1:6 complexes decompose in benzene to form the 1:3 species, except for [Pt(ETC)4]I2, which releases two ligand molecules to give trans-[Pt(ETC)2I2]. The 1:2 and 1:3 complexes have been tested for in vitro cytostatic activity against KB cells.

引用

页码：45 / 50

页数：6

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