MACQUARIMICINS, MICROBIAL METABOLITES FROM MICROMONOSPORA .2. ISOLATION AND STRUCTURAL ELUCIDATION

被引:25
作者
HOCHLOWSKI, JE
MULLALLY, MM
HENRY, R
WHITTERN, DM
MCALPINE, JB
机构
[1] New Lead Discovery, Abbott Laboratories, Abbott Park
关键词
D O I
10.7164/antibiotics.48.467
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A novel series of carbocyclic compounds has been isolated from two related Micromonospora cultures. The C-19 and C-22 macquarimicins represent different end products on a similar biosynthetic scheme. 1-D and 2-D homonuclear and heteronuclear NMR experiments allowed assignment of the basic structures of the macquarimicins. An X-ray structure of macquarimicin B suggested the stereochemistry for the series which was not discernible from spectroscopic data alone.
引用
收藏
页码:467 / 470
页数:4
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