Vascular Stiffness and Increased Pulse Pressure in the Aging Cardiovascular System

被引：129

作者：

Steppan, Jochen ^{[1
]}

Barodka, Viachaslau ^{[1
]}

Berkowitz, Dan E. ^{[1
]}

Nyhan, Daniel ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21287 USA

来源：

CARDIOLOGY RESEARCH AND PRACTICE | 2011年 / 2011卷

关键词：

D O I：

10.4061/2011/263585

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aging leads to a multitude of changes in the cardiovascular system, including systolic hypertension, increased central vascular stiffness, and increased pulse pressure. In this paper we will review the effects of age-associated increased vascular stiffness on systolic blood pressure, pulse pressure, augmentation index, and cardiac workload. Additionally we will describe pulse wave velocity as a method to measure vascular stiffness and review the impact of increased vascular stiffness as an index of vascular health and as a predictor of adverse cardiovascular outcomes. Furthermore, we will discuss the underlying mechanisms and how these may be modified in order to change the outcomes. A thorough understanding of these concepts is of paramount importance and has therapeutic implications for the increasingly elderly population.

引用

页数：8

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