1,8-DISUBSTITUTED ANALOGS OF [ILE5] AND [VAL5]ANGIOTENSIN II - DIFFERENCE IN POTENCY AND SPECIFICITY OF ANGIOTENSIN II ANTAGONISTIC ACTIVITY

被引：9

作者：

SCHOELKENS, BA ^{[1
]}

WISSMANN, H ^{[1
]}

LINDNER, E ^{[1
]}

GEIGER, R ^{[1
]}

机构：

[1] HOECHST AG, D-6230 FRANKFURT 80, BUNDES REPUBLIK

来源：

HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE | 1976年 / 357卷 / 06期

关键词：

D O I：

10.1515/bchm2.1976.357.1.825

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Depending on the species, position 5 in angiotensin II is occupied by isoleucine or valine. 1,8-Disubstituted analogs of [Ile5]angiotensin II show distinct differences from the corresponding [Val5]angiotensin II analogs in the potency and specificity of their inhibitory action [in guinea pig ileum and rat stomach]. The syntheses of new analogs are described.

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页码：825 / 838

页数：14

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