THE ROLE OF FUTILE CYCLES IN THE ENERGETICS OF BACTERIAL-GROWTH

被引:30
作者
NEIJSSEL, OM
BUURMAN, ET
DEMATTOS, MJT
机构
[1] Department of Microbiology, Biotechnology Centre, University of Amsterdam, Amsterdam
关键词
Active transport; Ammonia; Bacterial growth; Futile cycle; Potassium;
D O I
10.1016/0005-2728(90)90260-B
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this contribution we describe the occurrence of futile cycles in growing bacteria. These cycles are thought to be active when organisms contain two uptake systems for a particular nutrient (one with a high, the other with a low affinity for its substrate). The high-affinity system is responsible for uptake of the nutrient, some of which is subsequently lost to the medium again via leakage through the low-affinity-system. A special futile cycle is caused under some growth conditions by the extremely rapid diffusion of ammonia through bacterial membranes. When the ammonium ion is taken up via active transport, the couple NH3 NH+4 will act as an uncoupler. This is aggravated by the chemical similarity of the potassium and the ammonium ion, which leads to ammonium ion transport via the Kdp potassium transport system when the potassium concentration in the medium is low. Other examples of futile cycles, such as those caused by the production of fatty acids by fermentation, are briefly discussed. © 1990.
引用
收藏
页码:252 / 255
页数:4
相关论文
共 22 条
[1]  
BAKKER EP, 1983, FEMS MICROBIOL LETT, V16, P229
[2]   REPLACEMENT OF POTASSIUM-IONS BY AMMONIUM-IONS IN DIFFERENT MICROORGANISMS GROWN IN POTASSIUM-LIMITED CHEMOSTAT CULTURE [J].
BUURMAN, ET ;
PENNOCK, J ;
TEMPEST, DW ;
DEMATTOS, MJT ;
NEIJSSEL, OM .
ARCHIVES OF MICROBIOLOGY, 1989, 152 (01) :58-63
[3]  
CHAMBOST JP, 1980, J BIOL CHEM, V255, P2867
[4]   METABOLIC AND ENERGETIC ASPECTS OF THE GROWTH OF CLOSTRIDIUM-BUTYRICUM ON GLUCOSE IN CHEMOSTAT CULTURE [J].
CRABBENDAM, PM ;
NEIJSSEL, OM ;
TEMPEST, DW .
ARCHIVES OF MICROBIOLOGY, 1985, 142 (04) :375-382
[5]   ASSESSMENT OF A FUTILE CYCLE INVOLVING RECONVERSION OF FRUCTOSE 6-PHOSPHATE TO FRUCTOSE-1,6-BISPHOSPHATE DURING GLUCONEOGENIC GROWTH OF ESCHERICHIA-COLI [J].
DALDAL, F ;
FRAENKEL, DG .
JOURNAL OF BACTERIOLOGY, 1983, 153 (01) :390-394
[6]   EVIDENCE OF A QUINOPROTEIN GLUCOSE-DEHYDROGENASE APOENZYME IN SEVERAL STRAINS OF ESCHERICHIA-COLI [J].
HOMMES, RWJ ;
POSTMA, PW ;
NEIJSSEL, OM ;
TEMPEST, DW ;
DOKTER, P ;
DUINE, JA .
FEMS MICROBIOLOGY LETTERS, 1984, 24 (2-3) :329-333
[7]   THE FUNCTIONAL-SIGNIFICANCE OF GLUCOSE-DEHYDROGENASE IN KLEBSIELLA-AEROGENES [J].
HOMMES, RWJ ;
VANHELL, B ;
POSTMA, PW ;
NEIJSSEL, OM ;
TEMPEST, DW .
ARCHIVES OF MICROBIOLOGY, 1985, 143 (02) :163-168
[8]   BACTERIAL AMMONIUM TRANSPORT [J].
KLEINER, D .
FEMS MICROBIOLOGY LETTERS, 1985, 32 (02) :87-100
[10]  
LAIMINS LA, 1981, P NATL ACAD SCI-BIOL, V78, P464, DOI 10.1073/pnas.78.1.464