IMMUNOCYTOCHEMICAL AND LESION STUDIES SUPPORT THE HYPOTHESIS THAT THE PROJECTION FROM THE MEDIAL NUCLEUS OF THE TRAPEZOID BODY TO THE LATERAL SUPERIOR OLIVE IS GLYCINERGIC

被引：66

作者：

BLEDSOE, SC ^{[1
]}

SNEAD, CR ^{[1
]}

HELFERT, RH ^{[1
]}

PRASAD, V ^{[1
]}

WENTHOLD, RJ ^{[1
]}

ALTSCHULER, RA ^{[1
]}

机构：

[1] NIH,NEUROOTOLARYNGOL LAB,BETHESDA,MD 20205

来源：

BRAIN RESEARCH | 1990年 / 517卷 / 1-2期

关键词：

Glycine; Immunocytochemistry; Kainic acid; Lateral superior olive; Medial nucleus of the trapezoid body;

D O I：

10.1016/0006-8993(90)91025-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pre- and postembedding immunocytochemical techniques were used to study the distribution of glycine immunoreactivity in the superior olivary complex of guinea pigs following kainic acid (KA) lesios of the medial nucleus of the trapezoid body (MNTB). Destruction of the MNTB by injecting 50-100 nl of 10 mM KA virtually abolished labeled neurons in the MNTB at the site of the lesion. This resulted in a marked decrease in the number of labeled fibers projecting to the ipsilateral lateral superior olive (LSO) and in the number of labeled fibers and presynaptic terminals in the neuropil of the LSO. Smaller volumes (20 nl) of KA produced similar but more restricted changes that conformed to the topographic organization of the MNTB projection to the LSO. The results support the hypothesis that the MNTB to LSO pathway is glycinergic. © 1990.

引用

页码：189 / 194

页数：6

共 38 条

[1]

Aitkin L.M., 1984, HDB PHYSL 1, VIII, P675

[2] GLYCINE-LIKE IMMUNOREACTIVITY IN THE RAT AUDITORY PATHWAY [J].