THE SYNTHESIS OF 2-MORPHOLINE CARBOXYLIC-ACID DERIVATIVES AND THEIR ELABORATION TO 1-AZA-4-OXABICYCLO[3.3.1]NONAN-6-ONE

被引：9

作者：

KING, FD

MARTIN, RT

机构：

[1] SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD England, Coldharbour Road, The pinnacles

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(00)79702-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two syntheses of novel 2-morpholine carboxylic acid derivatives are described. The esters were converted into 1-aza-4-oxabicyclo[3.3.1]nonan-6-one, the first example of this ring system, which was further elaborated to the ortho-methoxy benzamide derivative (2).

引用

页码：2281 / 2284

页数：4

共 7 条

[1]

DUMIUS A, 1989, N-S ARCH PHARMACOL, V340, P403

[2] SUBSTITUTED BENZAMIDES WITH CONFORMATIONALLY RESTRICTED SIDE-CHAINS .1. QUINOLIZIDINE DERIVATIVES AS SELECTIVE GASTRIC PROKINETIC AGENTS [J].