SEROTONIN RECEPTORS AND THEIR LIGANDS - A LACK OF SELECTIVE AGENTS

被引:87
作者
GLENNON, RA
DUKAT, M
机构
[1] Department of Medicinal Chemistry, School of Pharmacy, Medical College, Richmond
关键词
SEROTONIN RECEPTORS; 5-HT1; 5-HT2; 5-HT3; 5-HT4; LIGANDS; BINDING;
D O I
10.1016/0091-3057(91)90121-H
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Four major families of serotonin (5-hydroxytryptamine; 5-HT) receptors have been identified: 5-HT1, 5-HT2, 5-HT3 and 5-HT4. At this time, there is a general consensus that the 5-HT1 family can be further subdivided into 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, and 5-HT1P subpopulations. In addition, there are several other populations of less well-defined 5-HT receptors. The purpose of this presentation is to discuss 5-HT receptor nomenclature and the agents that are commonly used to investigate each receptor population in as much as it will serve to provide background for the remainder of the symposium. There is presently available an abundance of serotonergic agents; however, these agents are only semiselective, and none can be considered truly selective for a particular population of 5-HT receptors. As useful as these agents have been for the identification and characterization of 5-HT receptors, there remains a need for the development of new, more selective ligands.
引用
收藏
页码:1009 / 1017
页数:9
相关论文
共 62 条
[1]  
[Anonymous], [No title captured]
[2]  
APPEL NM, 1990, J PHARMACOL EXP THER, V255, P843
[3]  
BAXTER GS, 1990, 2ND IUPHAR SAT M SER, P78
[4]  
BOULENGUEZ P, 1990, Society for Neuroscience Abstracts, V16, P694
[5]  
BRANCHEK T, 1990, MOL PHARMACOL, V38, P604
[6]  
BRANCHEK TA, 1990, 2ND IUPHAR SAT M SER, P35
[7]   (R)-(-)-10-METHYL-11-HYDROXYAPORPHINE - A HIGHLY SELECTIVE SEROTONERGIC AGONIST [J].
CANNON, JG ;
MOHAN, P ;
BOJARSKI, J ;
LONG, JP ;
BHATNAGAR, RK ;
LEONARD, PA ;
FLYNN, JR ;
CHATTERJEE, TK .
JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (02) :313-318
[8]   5-HT1A-RECEPTOR ANTAGONISM - N-ALKYL DERIVATIVES OF (R)-(-)-8,11-DIMETHOXYNORAPORPHINE [J].
CANNON, JG ;
JACKSON, H ;
LONG, JP ;
LEONARD, P ;
BHATNAGAR, RK .
JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (08) :1959-1962
[9]  
CONN PJ, 1987, J PHARMACOL EXP THER, V242, P552
[10]   THE PSYCHOPHARMACOLOGY OF 5-HT3 RECEPTORS [J].
COSTALL, B ;
NAYLOR, RJ ;
TYERS, MB .
PHARMACOLOGY & THERAPEUTICS, 1990, 47 (02) :181-202