DNA RECOGNITION CODE OF TRANSCRIPTION FACTORS IN THE HELIX-TURN-HELIX, PROBE HELIX, HORMONE-RECEPTOR, AND ZINC-FINGER FAMILIES

被引：100

作者：

SUZUKI, M ^{[1
]}

YAGI, N ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,SENDAI,MIYAGI 98077,JAPAN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 26期

关键词：

DNA-PROTEIN INTERACTION; HOMEODOMAIN; LEUCINE ZIPPER; TRANSCRIPTION FACTOR GATA;

D O I：

10.1073/pnas.91.26.12357

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have previously reported that in four transcription factor families the DNA-recognition rules can be described as (i) chemical rules, which list possible pairings between the 20 amino acid residues and the four DNA bases, and (ii) stereochemical rules, which describe the base and amino acid positions in contact. We have incorporated these rules into a computer program and examined the nature of the rules. Here we conclude that the DNA recognition rules are simple, logical, and consistent. The rules are specific enough to predict DNA-binding characteristics from a protein sequence.

引用

收藏

页码：12357 / 12361

页数：5

相关论文

共 45 条

[1] RECOGNITION OF A DNA OPERATOR BY THE REPRESSOR OF PHAGE-434 - A VIEW AT HIGH-RESOLUTION [J].

AGGARWAL, AK ;

RODGERS, DW ;

DROTTAR, M ;

PTASHNE, M ;

HARRISON, SC .

SCIENCE, 1988, 242 (4880) :899-907

[2] STRUCTURE OF THE REPRESSOR OPERATOR COMPLEX OF BACTERIOPHAGE 434 [J].

ANDERSON, JE ;

PTASHNE, M ;

HARRISON, SC .

NATURE, 1987, 326 (6116) :846-852

[3] PROTEIN DNA CONFORMATIONAL-CHANGES IN THE CRYSTAL-STRUCTURE OF A LAMBDA-CRO-OPERATOR COMPLEX [J].

BRENNAN, RG ;

RODERICK, SL ;

TAKEDA, Y ;

MATTHEWS, BW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (20) :8165-8169

[4] CO-CRYSTAL STRUCTURE OF THE HNF-3/FORK HEAD DNA-RECOGNITION MOTIF RESEMBLES HISTONE-H5 [J].

CLARK, KL ;

HALAY, ED ;

LAI, ES ;

BURLEY, SK .

NATURE, 1993, 364 (6436) :412-420

[5] THE DNA-BINDING ARM OF LAMBDA-REPRESSOR - CRITICAL CONTACTS FROM A FLEXIBLE REGION [J].

CLARKE, ND ;

BEAMER, LJ ;

GOLDBERG, HR ;

BERKOWER, C ;

PABO, CO .

SCIENCE, 1991, 254 (5029) :267-270

[6]

DEELEY M, 1992, J BACTERIOL, V151, P942

[7] USE OF A ZINC-FINGER CONSENSUS SEQUENCE FRAMEWORK AND SPECIFICITY RULES TO DESIGN SPECIFIC DNA-BINDING PROTEINS [J].

DESJARLAIS, JR ;

BERG, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (06) :2256-2260

[8] THE GCN4 BASIC REGION LEUCINE ZIPPER BINDS DNA AS A DIMER OF UNINTERRUPTED ALPHA-HELICES - CRYSTAL-STRUCTURE OF THE PROTEIN-DNA COMPLEX [J].

ELLENBERGER, TE ;

BRANDL, CJ ;

STRUHL, K ;

HARRISON, SC .

CELL, 1992, 71 (07) :1223-1237

[9] THE CRYSTAL-STRUCTURE OF A 2 ZINC-FINGER PEPTIDE REVEALS AN EXTENSION TO THE RULES FOR ZINC-FINGER DNA RECOGNITION [J].

FAIRALL, L ;

SCHWABE, JWR ;

CHAPMAN, L ;

FINCH, JT ;

RHODES, D .

NATURE, 1993, 366 (6454) :483-487

[10] HIN RECOMBINASE BOUND TO DNA - THE ORIGIN OF SPECIFICITY IN MAJOR AND MINOR-GROOVE INTERACTIONS [J].

FENG, JA ;

JOHNSON, RC ;

DICKERSON, RE .

SCIENCE, 1994, 263 (5145) :348-355

← 1 2 3 4 5 →