ERYTHROCYTE POLYAMINE LEVELS IN HUMAN PROSTATIC-CARCINOMA

被引:30
作者
CIPOLLA, B [1 ]
MOULINOUX, JP [1 ]
QUEMENER, V [1 ]
HAVOUIS, R [1 ]
MARTIN, LA [1 ]
GUILLE, F [1 ]
LOBEL, B [1 ]
机构
[1] CTR HOSP REG & UNIV RENNES,RECH THERAPEUT ANTICANCEREUSE GRP,RENNES,FRANCE
关键词
D O I
10.1016/S0022-5347(17)39682-9
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Abnormally high red blood cell polyamine levels were found in benign prostatic hyperplasia and in prostatic adenocarcinoma patients. In prostatic adenocarcinoma patients a relationship was noted between the importance of red blood cell spermidine and spermine concentrations, and the clinical stage of the disease (Whitmore classification). Considering prostatic adenocarcinoma patient populations, patients with metastases (groups 3 and 4) statistically differed from those without metastases (group 2). Furthermore, red blood cell polyamine level determination discriminated patients in the hormonal escape group (group 4) from those usually considered as hormone responsive (groups 2 and 3). No statistically significant correlation was observed between red blood cell polyamine levels and usual tumor markers (prostatic acid phosphatase and prostate specific antigen). These results confirmed that red blood cell polyamine levels must be considered as a circulating index of cell proliferation that might be of clinical importance during the long-term followup and treatment of prostatic adenocarcinoma patients.
引用
收藏
页码:1164 / 1166
页数:3
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