INDUCTION OF CHROMOSOMAL-ABERRATIONS BY DNASE-I

被引：11

作者：

FOLLE, GA ^{[1
]}

JOHANNES, C ^{[1
]}

OBE, G ^{[1
]}

机构：

[1] UNIV ESSEN GESAMTHSCH,DEPT GENET,W-4300 ESSEN 1,GERMANY

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1991年 / 59卷 / 06期

关键词：

D O I：

10.1080/09553009114551231

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chinese hamster ovary (CHO) cells were treated with bovine pancreatic DNase I using the method of electroporation. The enzyme induced chromosomal aberrations in a S-phase independent manner. The frequencies of polycentric chromosomes induced in the G1 phase of the cell cycle are positively correlated with the dose of DNase I. The distributions of DNase I-induced polycentric chromosomes were overdispersed.

引用

页码：1371 / 1378

页数：8

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