A STAGE SPECIFIC GENE EXPRESSED AT THE ONSET OF GAMETOCYTOGENESIS IN PLASMODIUM-FALCIPARUM

被引:55
作者
ALANO, P [1 ]
PREMAWANSA, S [1 ]
BRUCE, MC [1 ]
CARTER, R [1 ]
机构
[1] UNIV EDINBURGH, DEPT GENET, W MAINS RD, EDINBURGH EH9 3JN, MIDLOTHIAN, SCOTLAND
基金
英国惠康基金;
关键词
PLASMODIUM-FALCIPARUM; GAMETOCYTOGENESIS; SEXUAL DIFFERENTIATION; STAGE SPECIFIC TRANSCRIPTION;
D O I
10.1016/0166-6851(91)90201-G
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The gene encoding the gametocyte specific cytoplasmic protein Pfg 27/25 of the human malaria parasite Plasmodium falciparum has been cloned. The gene encodes a highly hydrophilic non-repetitive protein which does not share obvious homologies with other polypeptides. The stage specificity of Pfg 27/25 is controlled at the stage of the production of stable mRNA, which is detectable only in the sexual stages of the parasite, and contains long additional sequences outside the Pfg27/25 coding region. As the activation of Pfg27/25 gene expression occurs at an early stage of gametocytogenesis, the study of its regulation might provide information on the molecular events occurring after the parasite commitment to sexual differentiation and at the beginning of gametocyte formation.
引用
收藏
页码:81 / 88
页数:8
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