EXPRESSION OF IGF-I AND IGF-II MESSENGER-RNA IN BREAST-TISSUE

被引：83

作者：

PAIK, S

机构：

[1] Department of Pathology, Lombardi Cancer Center, Georgetown University, Washington DC

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1992年 / 22卷 / 01期

关键词：

BREAST TUMOR CELLS; EPITHELIAL CELLS; IGF-I; IGF-II; INSITU HYBRIDIZATION; INSULIN-LIKE GROWTH FACTORS; MESSENGER RNA; STROMAL CELLS;

D O I：

10.1007/BF01833331

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Expression of IGF-I and IGF-II was studied in human breast cancer tissues by in situ hybridization. IGF-I mRNA was detected only in stromal cells adjacent to normal breast epithelial cells. Stromal cells associated with the tumor cells did not contain IGF-I, nor did malignant or benign breast epithelial cells. In contrast, IGF-II mRNA was found in both the malignant epithelial cells and their adjacent stromal cells. These data imply that stromal cells associated with breast epithelium may switch expression from IGF-I to IGF-II during breast cancer evolution. This appearance of IGF-II expression may identify cancer-associated stromal cells that have a fetal phenotype.

引用

页码：31 / 38

页数：8

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