FAILURE OF PULMONARY CLEARANCE OF RHODOCOCCUS-EQUI INFECTION IN CD4+ T-LYMPHOCYTE-DEFICIENT TRANSGENIC MICE

被引：71

作者：

KANALY, ST

HINES, SA

PALMER, GH

机构：

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 11期

关键词：

D O I：

10.1128/IAI.61.11.4929-4932.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pulmonary clearance of Rhudococcus equi requires functional T lymphocytes. In this study, CD8+ T-lymphocyte-deficient transgenic mice cleared virulent R. equi from the lungs while infection in CD4+ T-lymphocyte-deficient transgenic mice persisted. Although both CD4+ and CD8+ T cells function early in pulmonary defense against R. equi, clearance is dependent on CD4+ T lymphocytes.

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页码：4929 / 4932

页数：4

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