PEPTIDIC ENDOTHELIN-1 RECEPTOR ANTAGONIST, BQ-123, AND NEUROPROTECTION

被引：36

作者：

FEUERSTEIN, G

GU, JL

OHLSTEIN, EH

BARONE, FC

YUE, TL

机构：

[1] Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia

来源：

PEPTIDES | 1994年 / 15卷 / 03期

关键词：

ENDOTHELIN; ENDOTHELIN RECEPTOR ANTAGONISTS; STROKE; HIPPOCAMPUS; BQ-123;

D O I：

10.1016/0196-9781(94)90207-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelin-1 (ET-1) is a potent cerebrovascular constrictor that has been implicated in brain ischemia. Utilizing the ET(A) receptor antagonist, BQ-123, the role of ET-1 in ischemic neuronal death following global ischemia was studied. BQ-123, administered ICV, either before and after ischemia or only after ischemia, increased hippocampal CA1 neuron survival in gerbils subjected to transient global ischemia. This study suggests that ET(A) receptor antagonists might be useful in neuronal salvage following stroke.

引用

页码：467 / 469

页数：3

共 15 条

[1]

BARONE FC, 1993, J CEREB BLOOD FLOW M, V14, P337

[2] THE IMPORTANCE OF BRAIN TEMPERATURE IN CEREBRAL ISCHEMIC-INJURY [J].