SYNTHESIS, BASE-PAIRING PROPERTIES AND NUCLEASE RESISTANCE OF OLIGOTHYMIDYLATE ANALOGS CONTAINING METHOXYPHOSPHORAMIDATE INTERNUCLEOSIDE LINKAGES

被引：5

作者：

PEYROTTES, S ^{[1
]}

VASSEUR, JJ ^{[1
]}

IMBACH, JL ^{[1
]}

RAYNER, B ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,CHIM BIOORGAN LAB,CNRS,URA 488,F-34095 MONTPELLIER,FRANCE

来源：

NUCLEOSIDES & NUCLEOTIDES | 1994年 / 13卷 / 10期

关键词：

D O I：

10.1080/15257779408013213

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A dithymidine N-methoxyphosphoramidate was synthesized and incorporated into oligothymidylate analogs. The analogs form less stable duplexes with poly dA and poly rA than the corresponding ''all diester'' oligomer. The instability is more pronounced with poly rA than with poly dA. The analogs were found to be highly resistant to nucleases.

引用

页码：2135 / 2149

页数：15

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