INHIBITION OF PROSTAGLANDIN BIOSYNTHESIS BY TOLFENAMIC ACID INVITRO

被引：50

作者：

LINDEN, IB

PARANTAINEN, J

VAPAATALO, H

机构：

[1] MEDICA LTD, RES LABS, SF-00101 HELSINKI 10, FINLAND

[2] UNIV TAMPERE, INST BIOMED SCI, SF-33520 TAMPERE 52, FINLAND

来源：

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 1976年 / 5卷 / 03期

关键词：

D O I：

10.3109/03009747609165450

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of tolfenamic acid on prostaglandin biosynthesis was investigated by using rabbit kidney medulla microsomal fraction, the results were compared with those obtained with indomethacin and acetylsalicylic acid. Tolfenamic acid inhibited the conversion of arachidonic acid to prostaglandin E2 very effectively and in a dose-dependent manner. IC50 [concentration producing 50% inhibition] values were 0.64 .mu.M for tolfenamic acid, 0.76 .mu.M for indomethacin, and 7 mM for acetylsalicyclic acid. The inhibition of prostaglandin biosynthesis may be related to the good anti-inflammatory action of tolfenamic acid.

引用

页码：129 / 132

页数：4

共 17 条

[1] INHIBITION OF PROSTAGLANDIN SYNTHETASE SYSTEMS IN OCULAR TISSUES BY INDOMETHACIN [J].