LOW BRAIN UPTAKE OF L-[C-11]5-HYDROXYTRYPTOPHAN IN MAJOR DEPRESSION - A POSITRON EMISSION TOMOGRAPHY STUDY ON PATIENTS AND HEALTHY-VOLUNTEERS

被引:62
作者
AGREN, H
REIBRING, L
HARTVIG, P
TEDROFF, J
BJURLING, P
HORNFELDT, K
ANDERSSON, Y
LUNDQVIST, H
LANGSTROM, B
机构
[1] UNIV HOSP UPPSALA, DEPT NEUROL, S-75185 UPPSALA, SWEDEN
[2] UNIV UPPSALA, DEPT ORGAN CHEM, S-75105 UPPSALA, SWEDEN
[3] UNIV UPPSALA, SVEDBERG LAB, S-75105 UPPSALA, SWEDEN
关键词
POSITRON EMISSION TOMOGRAPHY; DEPRESSION; 5-HYDROXYTRYPTOPHAN; SEROTONIN; BLOOD-BRAIN BARRIER;
D O I
10.1111/j.1600-0447.1991.tb05574.x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The precursor of serotonin, L-5-hydroxytryptophan (L-5-HTP), was radio-labelled with C-11 in the beta-position, yielding [beta-C-11]serotonin after decarboxylation, allowing positron emission tomography studies of L-5-HTP uptake across the blood-brain barrier. We studied 8 healthy volunteers and 6 patients with histories of DSM-III major depression, 2 with repeated examinations after clinically successful treatment. We report a significantly lower uptake of [C-11]5-HTP across the blood-brain barrier in depressed patients, irrespective of phase of illness. The findings emphasize that serotonin is involved in depressive pathophysiology and support earlier suggestions that the transport of 5-HTP across the blood-brain barrier is compromised in major depression.
引用
收藏
页码:449 / 455
页数:7
相关论文
共 41 条
[1]   INTERACTING NEUROTRANSMITTER SYSTEMS - A NONEXPERIMENTAL APPROACH TO THE 5HIAA-HVA CORRELATION IN HUMAN CSF [J].
AGREN, H ;
MEFFORD, IN ;
RUDORFER, MV ;
LINNOILA, M ;
POTTER, WZ .
JOURNAL OF PSYCHIATRIC RESEARCH, 1986, 20 (03) :175-193
[2]  
AGREN H, 1988, PROGR CATECHOLAMIN C, P307
[3]  
ASHCROFT GW, 1972, LANCET, V2, P573
[4]  
BAXTER LR, 1989, ARCH GEN PSYCHIAT, V46, P243
[5]   A PROCEDURE FOR CALIBRATING AND CORRECTING DATA TO ACHIEVE ACCURATE QUANTITATIVE VALUES IN POSITRON EMISSION TOMOGRAPHY [J].
BERGSTROM, M ;
ERIKSSON, L ;
BOHM, C ;
BLOMQVIST, G ;
GREITZ, T ;
LITTON, J ;
WIDEN, L .
IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 1982, 29 (01) :555-557
[6]  
BERMAN KF, 1988, ARCH GEN PSYCHIAT, V45, P616
[7]   DETERMINATION OF MONOAMINE AND MONOAMINE METABOLITES IN HUMAN BRAIN - POST-MORTEM STUDIES IN A GROUP OF SUICIDES AND IN A CONTROL GROUP [J].
BESKOW, J ;
GOTTFRIES, CG ;
ROOS, BE ;
WINBLAD, B .
ACTA PSYCHIATRICA SCANDINAVICA, 1976, 53 (01) :7-20
[8]   ENZYMATIC-SYNTHESIS OF CARBOXY-C-11-LABELED L-TYROSINE, L-DOPA, L-TRYPTOPHAN AND 5-HYDROXY-L-TRYPTOPHAN [J].
BJURLING, P ;
ANTONI, G ;
WATANABE, Y ;
LANGSTROM, B .
ACTA CHEMICA SCANDINAVICA, 1990, 44 (02) :178-182
[9]  
BJURLING P, 1990, ACTA CHEM SCAND, V1, P555
[10]  
BLOOM FE, 1972, FED PROC, V31, P97