EXPRESSION OF MMP-7(PUMP-1) MESSENGER-RNA IN HUMAN COLORECTAL CANCERS

被引：137

作者：

YOSHIMOTO, M ^{[1
]}

ITOH, F ^{[1
]}

YAMAMOTO, H ^{[1
]}

HINODA, Y ^{[1
]}

IMAI, K ^{[1
]}

YACHI, A ^{[1
]}

机构：

[1] SAPPORO MED UNIV,SCH MED,DEPT INTERNAL MED,SECT 1,S-1,W-16,CHUO KU,SAPPORO 060,JAPAN

来源：

INTERNATIONAL JOURNAL OF CANCER | 1993年 / 54卷 / 04期

关键词：

D O I：

10.1002/ijc.2910540415

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expression of MMP-7 (pump-1)gene was examined in 10 cases of colorectal cancer by utilizing RT-PCR. In 9 out of 10 cases, MMP-7 mRNA was detected in cancerous tissue, whereas none was detected in adjacent normal colon tissue. However, this message was detected in only 1 out of 6 colon-cancer cell lines. In colonic mucosa from 3 patients with ulcerative colitis it was not detected. The expression of MMP-2 (72-kDa type-IV collagenase) mRNA was also investigated in the same tissue samples, and was detected in all samples, including cancerous and non-cancerous tissue. Our data suggest that MMP-7 is expressed in a tumor-associated manner in colorectal cancers and may play a role in tumor progression. (C) 1993 Wiley-Liss, Inc.

引用

页码：614 / 618

页数：5

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