RELATION BETWEEN MECONIUM CONCENTRATION OF THE COCAINE METABOLITE BENZOYLECGONINE AND FETAL GROWTH

被引：51

作者：

MIROCHNICK, M

FRANK, DA

CABRAL, H

TURNER, A

ZUCKERMAN, B

机构：

[1] BOSTON UNIV, SCH MED, BOSTON, MA 02118 USA

[2] BOSTON UNIV, SCH PUBL HLTH, BOSTON, MA USA

[3] BOSTON CITY HOSP, GEN CLIN RES CTR, BOSTON, MA 02118 USA

来源：

JOURNAL OF PEDIATRICS | 1995年 / 126卷 / 04期

关键词：

D O I：

10.1016/S0022-3476(95)70367-5

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Among 95 term infants with benzoylecgonine, the cocaine metabolite, detectable in their meconium, there was an inverse relation between the concentration of benzoylecgonine and birth weight, length, and head circumference. Multiple regression analysis confirmed these relations after controlling for gestational age and maternal use of marijuana, cigarettes, and alcohol. These data suggest a dose-response relation between the magnitude of prenatal cocaine exposure and impaired fetal growth.

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收藏

页码：636 / 638

页数：3

相关论文

共 10 条

[1] TERATOGENICITY OF COCAINE IN HUMANS [J].

BINGOL, N ;

FUCHS, M ;

DIAZ, V ;

STONE, RK ;

GROMISCH, DS .

JOURNAL OF PEDIATRICS, 1987, 110 (01) :93-96

[2] MEASUREMENT OF GESTATIONAL COCAINE EXPOSURE - SENSITIVITY OF INFANTS HAIR, MECONIUM, AND URINE [J].

CALLAHAN, CM ;

GRANT, TM ;

PHIPPS, P ;

CLARK, G ;

NOVACK, AH ;

STREISSGUTH, AP ;

RAISYS, VA .

JOURNAL OF PEDIATRICS, 1992, 120 (05) :763-768

[3] COCAINE AND PREGNANCY - CLINICAL AND METHODOLOGIC ISSUES [J].

CHASNOFF, IJ .

CLINICS IN PERINATOLOGY, 1991, 18 (01) :113-123

[4] THE PUZZLE OF COCAINE EFFECTS FOLLOWING MATERNAL USE DURING PREGNANCY - ARE THERE RECONCILABLE DIFFERENCES [J].

HUTCHINGS, DE .

NEUROTOXICOLOGY AND TERATOLOGY, 1993, 15 (05) :281-286

[5]

MIROCHNICK M, 1992, Pediatric Research, V31, p63A

[6] PERINATAL COCAINE AND METHAMPHETAMINE EXPOSURE - MATERNAL AND NEONATAL CORRELATES [J].

ORO, AS ;

DIXON, SD .

JOURNAL OF PEDIATRICS, 1987, 111 (04) :571-578

[7]

OSTREA EM, 1992, PEDIATRICS, V89, P107

[8] DETECTION OF PRENATAL DRUG EXPOSURE IN THE PREGNANT WOMAN AND HER NEWBORN-INFANT [J].

OSTREA, EM ;

WELCH, RA .

CLINICS IN PERINATOLOGY, 1991, 18 (03) :629-645

[9] DRUG SCREENING OF MECONIUM IN INFANTS OF DRUG-DEPENDENT MOTHERS - AN ALTERNATIVE TO URINE TESTING [J].

OSTREA, EM ;

BRADY, MJ ;

PARKS, PM ;

ASENSIO, DC ;

NALUZ, A .

JOURNAL OF PEDIATRICS, 1989, 115 (03) :474-477

[10] EFFECTS OF MATERNAL MARIJUANA AND COCAINE USE ON FETAL GROWTH [J].

ZUCKERMAN, B ;

FRANK, DA ;

HINGSON, R ;

AMARO, H ;

LEVENSON, SM ;

KAYNE, H ;

PARKER, S ;

VINCI, R ;

ABOAGYE, K ;

FRIED, LE ;

CABRAL, H ;

TIMPERI, R ;

BAUCHNER, H .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (12) :762-768