TOXICITY AND PATHOLOGICAL EFFECTS OF ORALLY-ADMINISTERED IVERMECTIN IN ATLANTIC, CHINOOK, AND COHO SALMON AND STEELHEAD TROUT

被引：35

作者：

JOHNSON, SC ^{[1
]}

KENT, ML ^{[1
]}

WHITAKER, DJ ^{[1
]}

MARGOLIS, L ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA, DEPT ZOOL, VANCOUVER V6T 2A9, BC, CANADA

来源：

DISEASES OF AQUATIC ORGANISMS | 1993年 / 17卷 / 02期

关键词：

IVERMECTIN; ONCORHYNCHUS-KISUTCH; ONCORHYNCHUS-MYKISS; ONCORHYNCHUS-TSHAWYTSCHA; PARASITE CONTROL; PARASITE TREATMENT; PATHOLOGICAL EFFECTS; SALMO-SALAR; SEA LICE; SUBLETHAL EFFECTS; TOXICITY;

D O I：

10.3354/dao017107

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Because ivermectin (22,23-Dihydroavermectin B1) has been proposed as an oral treatment against sea lice infections of farmed salmonids, we investigated the toxicity and pathological effects of various doses of ivermectin administered orally every second day to steelhead trout Oncorhynchus mykiss, coho salmon Oncorhynchus kisutch, chinook salmon Oncorhynchus tshawytscha and Atlantic salmon Salmo salar under laboratory conditions. These species differed in their ability to tolerate ivermectin, with coho salmon the most tolerant followed by chinook, then Atlantic salmon. Unequivocal results for steelhead trout were not obtained due to a secondary disease outbreak (vibriosis). Histological examination of the major organ systems revealed no pathological changes that could be associated with ivermectin toxicity in any of the salmon species tested.

引用

页码：107 / 112

页数：6

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