EXPRESSION OF THE D3 DOPAMINE-RECEPTOR GENE AND A NOVEL VARIANT TRANSCRIPT GENERATED BY ALTERNATIVE SPLICING IN HUMAN PERIPHERAL-BLOOD LYMPHOCYTES

被引：69

作者：

NAGAI, Y

UENO, S

SAEKI, Y

SOGA, F

YANAGIHARA, T

机构：

[1] OSAKA UNIV,SCH MED,DEPT NEUROL,2-2 YAMADAOKA,SUITA,OSAKA 565,JAPAN

[2] OSAKA UNIV,SCH MED,DEPT INTERNAL MED 2,SUITA,OSAKA 565,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 194卷 / 01期

关键词：

D O I：

10.1006/bbrc.1993.1829

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sequential reverse transcription and polymerase chain reaction amplified the mRNA coding for the D3 dopamine receptor (D3R) in human peripheral blood lymphocytes. Pharmacological analysis confirmed the binding of the D3R specific ligand to the lymphocytes. In addition, there was a novel shorter variant transcript of the D3R gene generated by alternative splicing in lymphocytes and brain. This variant, termed D3(TM4-del), has a 143 bp deletion and encodes a 138 amino acid protein containing the first three transmembrane domains of the native D3R. © 1993 Academic Press, Inc.

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页码：368 / 374

页数：7

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