BERNINAMYCIN-B, BERNINAMYCIN-C, AND BERNINAMYCIN-D, MINOR METABOLITES FROM STREPTOMYCES-BERNENSIS

被引：32

作者：

LAU, RCM ^{[1
]}

RINEHART, KL ^{[1
]}

机构：

[1] UNIV ILLINOIS, ROGER ADAMS LAB, URBANA, IL 61801 USA

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 12期

关键词：

D O I：

10.7164/antibiotics.47.1466

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Berninamycins B, C, and D were isolated from fermentation of Streptomyces bernensis and their structures were studied with C-13 NMR and FAB mass spectrometry. Berninamycin B has a valine unit in its cyclic peptide loop instead of the beta-hydroxyvaline unit found in berninamycin A. Berninamycin D has two fewer dehydroalanine units attached to the carboxyl carbon of the pyridine ring. Based on FAB-MS results, berninamycin C is postulated to have only one dehydroalanine unit attached to the carboxyl carbon of pyridine. The biogenesis of berninamycins B, C, and D is discussed.

引用

页码：1466 / 1472

页数：7

共 16 条

[1]

ABE H, 1978, TETRAHEDRON LETT, P2791

[2] THE STRUCTURES OF SULFOMYCIN-I AND BERNINAMYCIN-A [J].