ACUTE RELEASE OF TISSUE-TYPE PLASMINOGEN-ACTIVATOR (T-PA) FROM THE ENDOTHELIUM - REGULATORY MECHANISMS AND THERAPEUTIC TARGET

被引：14

作者：

SCHRAUWEN, Y

DEVRIES, REM

KOOISTRA, T

EMEIS, JJ

机构：

[1] Gaubius Laboratory TNO-PG, 2300 AK Leiden

来源：

FIBRINOLYSIS | 1994年 / 8卷

关键词：

TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA); ENDOTHELIUM; REGULATED SECRETION; FIBRINOLYSIS;

D O I：

10.1016/0268-9499(94)90230-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The acute release of t-PA was studied in vitro in human endothelial cells from different origin. It proved possible to enhance the amounts of t-PA which can be released by increasing t-PA synthesis, both in vitro, and in vivo in rats. These data suggest the feasibility to induce and (or) enhance acute release of t-PA in man.

引用

页码：8 / 12

页数：5

共 12 条

[1]

BOOTH F, 1988, Fibrinolysis, V2, P107, DOI 10.1016/0268-9499(88)90374-8

[2] RAPID RELEASE AND DEACTIVATION OF PLASMINOGEN ACTIVATORS IN HUMAN-ENDOTHELIAL CELL-CULTURES IN THE PRESENCE OF THROMBIN AND IONOPHORE A23187 [J].