THE AMPA ANTAGONIST NBQX PROVIDES PARTIAL PROTECTION OF RAT CEREBELLAR PURKINJE-CELLS AFTER CARDIAC-ARREST AND RESUSCITATION

被引：29

作者：

BRASKO, J

RAI, P

SABOL, MK

PATRIKIOS, P

ROSS, DT

机构：

[1] UNIV PENN,DIV NEUROSURG,CTR HEAD INJURT,PHILADELPHIA,PA 19104

[2] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT PATHOL ANAT & CELL BIOL,PHILADELPHIA,PA 19107

[3] UNIV ROCHESTER,DEPT ANAT & NEUROBIOL,ROCHESTER,NY 14642

[4] MED COLL PENN,PHILADELPHIA,PA 19125

[5] HAHNEMANN UNIV,ANIM RESOURCES LAB,PHILADELPHIA,PA 19125

来源：

BRAIN RESEARCH | 1995年 / 699卷 / 01期

关键词：

CARDIAC ARREST; ISCHEMIA; CEREBELLAR DEGENERATION; NEUROPROTECTION; AMPA ANTAGONIST;

D O I：

10.1016/0006-8993(95)01015-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Purkinje cell loss in adult rats resuscitated following cardiac arrest is analogous to that seen following human cardiac arrest. Administration of the competitive AMPA antagonist NBQX to rats resuscitated after 10 min duration cardiac arrest rescued 21.5% of the vulnerable Purkinje cell population. These results support the hypothesis that sustained postischemic overexcitation of AMPA receptors may be a driving force in the process of Purkinje cell degeneration.

引用

页码：133 / 138

页数：6

共 36 条

[1] RESPONSES TO EXCITATORY AMINO-ACIDS OF PURKINJE-CELLS AND NEURONS OF THE DEEP NUCLEI IN CEREBELLAR SLICE CULTURES
AUDINAT, E
KNOPFEL, T
GAHWILER, BH
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1990, 430 : 297 - 313
[2] BALCHEN T, 1993, NEUROPHARM NEUROTOX, V3, P785
[3] BAUDE A, 1994, J NEUROSCI, V14, P2830
[4] Brasko J., 1993, Society for Neuroscience Abstracts, V19, P1659
[5] BRORSON JR, 1994, J NEUROSCI, V14, P187
[6] BLOCKADE OF THE AMPA RECEPTOR PREVENTS CA1 HIPPOCAMPAL INJURY FOLLOWING SEVERE BUT TRANSIENT FOREBRAIN ISCHEMIA IN ADULT-RATS
BUCHAN, AM
LI, H
CHO, S
PULSINELLI, WA
[J]. NEUROSCIENCE LETTERS, 1991, 132 (02) : 255 - 258
[7] PROTECTION AGAINST ISCHEMIC HIPPOCAMPAL CA1 DAMAGE IN THE RAT WITH A NEW NON-NMDA ANTAGONIST, NBQX
DIEMER, NH
JORGENSEN, MB
JOHANSEN, FF
SHEARDOWN, M
HONORE, T
[J]. ACTA NEUROLOGICA SCANDINAVICA, 1992, 86 (01): : 45 - 49
[8] REGIONAL NEURON DAMAGE AFTER CEREBRAL-ISCHEMIA IN THE NORMOGLYCEMIC AND HYPOGLYCEMIC RAT
DIEMER, NH
SIEMKOWICZ, E
[J]. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1981, 7 (03) : 217 - 227
[9] POSTNATAL-DEVELOPMENT OF THE CHEMOSENSITIVITY OF RAT CEREBELLAR PURKINJE-CELLS TO EXCITATORY AMINO-ACIDS - AN INVITRO STUDY
DUPONT, JL
GARDETTE, R
CREPEL, F
[J]. DEVELOPMENTAL BRAIN RESEARCH, 1987, 34 (01): : 59 - 68
[10] ANTIGENIC COMPARTMENTATION IN THE MOUSE CEREBELLAR CORTEX - ZEBRIN AND HNK-1 REVEAL A COMPLEX, OVERLAPPING MOLECULAR TOPOGRAPHY
EISENMAN, LM
HAWKES, R
[J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1993, 335 (04) : 586 - 605

← 1 2 3 4 →