IMPROVED BIOCOMPATIBILITY OF INTRAOCULAR LENSES BY HEPARIN SURFACE MODIFICATION - A 12-MONTH IMPLANTATION STUDY IN MONKEYS

被引：34

作者：

SPANGBERG, M

KIHLSTROM, I

BJORKLUND, H

BJURSTROM, S

LYDAHL, E

LARSSON, R

机构：

[1] Pharmacia Ophthalmics AB, Pharmacia LEO Therapeutics AB, Uppsala

来源：

JOURNAL OF CATARACT AND REFRACTIVE SURGERY | 1990年 / 16卷 / 02期

关键词：

heparin surface modification; implantation; intraocular lens; monkey; posterior chamber;

D O I：

10.1016/S0886-3350(13)80726-2

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

To evaluate the long-term biocompatibility and potential side effects of heparin surface modification of a poly(methyl methacrylate) intraocular lens (IOL), a heparin surface modified IOL was implanted in the left posterior chamber of 24 cynomolgus monkeys and a reference IOL (without surface modification) was implanted in the right eye in 12 of these animals. Twelve eyes were not operated on. Eleven eyes in seven monkeys were lens extracted as a control of the surgical method. Slitlamp examinations and intraocular pressure recordings were made one day, one and two weeks, and 1, 2, 2 1/2, 3 1/2, 6, 8, 10, and 12 months after the operation. Eleven monkeys were sacrificed after 3 1/2 months and the remaining animals after 12 months for morphological examination of the eyes. Slitlamp and morphological examinations showed that cell deposits, pigmentation, and posterior synechias were significantly less in eyes with heparin surface modified IOLs than in eyes with reference IOLs throughout the 12-month observation period. The intraocular pressure was equally reduced in eyes with heparin surface modified IOLs and reference IOLs for about one month, after which it returned to normal. No side effects following the implantation of heparin surface modified I0Ls were observed. We concluded that heparin surface modification of IOLs is efficient for long-term reduction of cell deposits and posterior synechias after implantation in monkey eyes and may also be effective in lowering the degree of side effects to IOL implantation in humans. © 1990, American Society of Cataract and Refractive Surgery. All rights reserved.

引用

页码：170 / 177

页数：8

共 19 条

[1]

Kaufman HE, Katz J, Valentin J, Sheets JW, Et al., Corneal endothelium damage with intraocular lenses

[2]

contact adhesion between surgical materials and tissue, Science, 198, pp. 525-527, (1977)

[3]

Bohnke M, Draeger J, Schneider M, Effects of Healon® and methylcellulose in protecting the cornea from mechanical trauma during surgery, Implant, 4, pp. 2-7, (1986)

[4]

Ohara K, Biomicroscopy of surface deposits resembling foreign-body giant cells on implanted intraocular lenses, Am J Ophthalmol, 99, pp. 304-311, (1985)

[5]

Puck A, Tso MOM, Yue B, Cellular deposits on intraocular lenses, Acta Ophthalmol Suppl, 170, pp. 54-60, (1985)

[6]

Bryan JA, Peiffer RL, Brown DT, Eifrig DE, Et al., Morphology of pseudophakic precipitates on intraocular lenses removed from human patients, Am Intra-Ocular Implant Soc J, 11, pp. 260-267, (1985)

[7]

Wolter JR, Foreign body giant cells selectively covering haptics of intraocular lens implants: Indicators of poor toleration?, Ophthalmic Surg, 14, pp. 839-844, (1983)

[8]

Apple DJ, Craythorn JM, Olson RJ, Little LE, Et al., Anterior segment complications and neovascular glaucoma following implantation of a posterior chamber intraocular lens, Ophthalmology, 91, pp. 403-419, (1984)

[9]

Wolter JR, Cytopathology of intraocular lens implantation, Ophthalmology, 92, pp. 135-142, (1985)

[10]

Mondino BJ, Nagata S, Glovsky MM, Activation of the alternative complement pathway by intraocular lenses, Invest Ophthalmol Vis Sci, 26, pp. 905-908, (1985)

← 1 2 →