INTRACEREBROVENTRICULAR MYOINOSITOL ANTAGONIZES LITHIUM-INDUCED SUPPRESSION OF REARING BEHAVIOR IN RATS

被引：42

作者：

KOFMAN, O

BELMAKER, RH

机构：

[1] Beer-Sheva Mental Health Center, Ben Gurion University of the Negev, Beer-Sheva

来源：

BRAIN RESEARCH | 1990年 / 534卷 / 1-2期

关键词：

Intracerebroventricular; Lithium; Locomotor activity; Myo-inositol;

D O I：

10.1016/0006-8993(90)90155-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several biological effects of lithium have been reversed by in vitro myo-inositol. To determine if intracerebroventricular myo-inositol would reverse behavioural effects of lithium, rats were injected with 5 meq/kg lithium choloride or sodium chloride and injected intracranially with myo-inositol (10 mg) or artificial CSF 24 h and 15 min prior to measurement of activity in an automated activity monitor. Myo-inositol alone had no significant effect on behaviour, but significantly reversed suppression of rearing activity by lithium. © 1990.

引用

页码：345 / 347

页数：3

共 28 条

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