ANTIULCER MECHANISM OF ACTION OF REBAMIPIDE, A NOVEL ANTIULCER COMPOUND, ON DIETHYLDITHIOCARBAMATE-INDUCED ANTRAL GASTRIC-ULCERS IN RATS

被引：100

作者：

OGINO, K ^{[1
]}

HOBARA, T ^{[1
]}

ISHIYAMA, H ^{[1
]}

YAMASAKI, K ^{[1
]}

KOBAYASHI, H ^{[1
]}

IZUMI, Y ^{[1
]}

OKA, S ^{[1
]}

机构：

[1] KOKURA MEM HOSP,KITAKYUSHU,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 212卷 / 01期

关键词：

DIETHYLDITHIOCARBAMATE-INDUCED ANTRAL ULCER; NEUTROPHIL; REBAMIPIDE;

D O I：

10.1016/0014-2999(92)90065-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mechanism of the inhibitory action of rebamipide, a new mucosal protective drug, was studied using rats with diethyldithiocarbamate-induced gastric antral ulcers. Rebamipide reduced ulcer formation and inhibited the elevation in lipid peroxide concentration in the gastric mucosa. Rebamipide inhibited both luminol- and lucigenin-dependent chemiluminescence of neutrophils activated by formyl-methionyl-leucyl-phenylalanine. Rebamipide did not alter the reduction of cytochrome c induced by the xanthine-xanthine oxidase system or the NADPH-dependent micirosomal lipid peroxidation in the liver. These findings suggest that rebamipide prevents diethyldithiocarbamate-induced gastric ulcer formation by inhibiting neutrophil activation.

引用

页码：9 / 13

页数：5

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