SEROTONERGIC PATHOLOGY IS NOT WIDESPREAD IN ALZHEIMER PATIENTS WITHOUT PROMINENT AGGRESSIVE SYMPTOMS

被引：70

作者：

PROCTER, AW ^{[1
]}

FRANCIS, PT ^{[1
]}

STRATMANN, GC ^{[1
]}

BOWEN, DM ^{[1
]}

机构：

[1] UNIV MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT PSYCHIAT,LONDON SE1 9RT,ENGLAND

来源：

NEUROCHEMICAL RESEARCH | 1992年 / 17卷 / 09期

关键词：

ALZHEIMERS DISEASE; BEHAVIOR; SEROTONIN; CEREBRAL CORTEX;

D O I：

10.1007/BF00993268

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Behavioural symptoms of Alzheimer's disease, such as aggression, may determine the care patients required. Most postmortem neurochemical studies have been of institutionalized patients and conclusions drawn from these may not be valid for all patients. We have shown that serotonin 2 receptors are not lost from 12 of the 13 areas of cerebral cortex examined in the patients assessed to be free of aggressive symptoms. This has been interpreted as representing the relative preservation of cortical interneurones. In contrast choline acetyltransferase activity was reduced in all areas whereas serotonin content was reduced in only 2 of the 4 areas examined.

引用

页码：917 / 922

页数：6

共 35 条

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