TRICYCLIC CEPHEMS AS INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE - FURO[3,4-C]CEPHAM SULFONES

被引：8

作者：

ALPEGIANI, M

BISSOLINO, P

CORIGLI, R

RIZZO, V

PERRONE, E

机构：

[1] Pharmacia Farmitalia Carlo Erba S.r.l., 20014 Nerviano, Milano

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 07期

关键词：

D O I：

10.1016/0960-894X(95)00094-A

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Furo[3,4-c]cepham sulfones were efficiently obtained from 1,1-dioxo-3-methylcephem-4-ketones. Cyclization improved at one time stability of the beta-lactam towards hydrolytic cleavage (pH 7.4) and reactivity(second-order inhibition rate constant k(cm)) towards human leukocyte elastase.

引用

页码：687 / 690

页数：4

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