NO EVIDENCE FOR DIFFERENCES BETWEEN PRE-JUNCTIONAL AND POST-JUNCTIONAL ALPHA-2-ADRENOCEPTORS

被引:29
作者
DOCHERTY, JR
HYLAND, L
机构
关键词
D O I
10.1111/j.1476-5381.1985.tb08901.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1 We have examined the pre- and post-junctional effects of a series of .alpha.-adrenoceptor agonists and antagonists at .alpha.2-adrenoceptors in the pithed rat preparation and the human isolated saphenous vein. 2 In the pithed rat, there was no differnce in relative agonist and antagonist potencies between pre- and post-junctional .alpha.2-adrenoceptors but the absolute potencies of antagonists differed: antagonists were more potent prejunctionally. 3 In the human saphenous vein, the .alpha.2-adrenoceptor antagonist yohimbine had pre- and post-junctional actions over the same concentration range. 4 We have no evidence to suggest differences between pre- and post-junctional .alpha.2-adrenoceptors; differences in absolute antagonist potencies in the pithed rat may be due to non-equilibrium conditions.
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页码:335 / 339
页数:5
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