THE RELATIONSHIP OF ABNORMALITIES OF CELLULAR-IMMUNITY TO ANTIBODIES TO HTLV-III IN HOMOSEXUAL MEN

被引：28

作者：

DOBOZIN, BS

JUDSON, FN

COHN, DL

PENLEY, KA

RICKMANN, PE

BLASER, MJ

SARIN, PS

WEISS, SH

KIRKPATRICK, CH

机构：

[1] NATL JEWISH HOSP & RES CTR, DEPT MED, CONRAD D STEPHENSON LAB RES IMMUNOL, 3800 E COLFAX AVE, DENVER, CO 80206 USA

[2] NATL JEWISH HOSP & RES CTR, DEPT MED, ANNA PERAHIA ADATTO CLIN RES CTR, DENVER, CO 80206 USA

[3] DEPT HLTH & HOSP, DENVER DIS CONTROL SERV, DENVER, CO 80204 USA

[4] VET ADM MED CTR, INFECT DIS SECT, DENVER, CO 80220 USA

[5] NCI, DIV CANC TREATMENT, TUMOR CELL BIOL LAB, BETHESDA, MD 20892 USA

[6] NCI, DIV CANC ETIOL, ENVIRONM EPIDEMIOL BRANCH, BETHESDA, MD 20892 USA

来源：

CELLULAR IMMUNOLOGY | 1986年 / 98卷 / 01期

关键词：

D O I：

10.1016/0008-8749(86)90276-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A comprehensive evaluation of the cellular immune system (total T-cell, helper cell, suppressor cell, and natural killer cell numbers; in vitro interleukin-2 production, T-cell responses to mitogens and antigens, serum .beta.2 microglobulin levels, and delayed hypersensitivity skin tests) was performed on 36 HTLV-III seronegative and 16 HTLV-III seropositive healthy homosexual men, 48 asymptomatic homosexual men with the chronic lymphadenopathy syndrome, 41 patients with AIDS, and 29 heterosexual controls without any known risk factors for AIDS. Our studies demonstrate that HTLV-III seronegative homosexual men have normal cellular immunity and are comparable to heterosexual controls. The abnormalities of lymphocyte subsets observed in HTLV-III seropositive healthy homosexual men are comparable to subjects with chronic lymphadenopathy. Assays of lymphocyte function, with the exception of delayed type hypersensitivity (DTH) skin tests, are similar in each group except patients with AIDS. Subjects with chronic lymphadenopathy were less responsive to DTH skin tests and HTLV-III seropositive healthy homosexuals were comparable to chronic lymphadenopathy subjects. We conclude that immunologic abnormalities in homosexual men are attributable to infection with HTLV-III.

引用

页码：156 / 171

页数：16

共 25 条

[1] GROWTH RATES OF MIXED LEUKOCYTE CULTURES [J].

ALLING, DW ;

KAHAN, BD .

TRANSPLANTATION, 1969, 8 (01) :1-&

[2]

ANDERSON DJ, 1982, J IMMUNOL, V128, P535

[3] ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) [J].

BARRESINOUSSI, F ;

CHERMANN, JC ;

REY, F ;

NUGEYRE, MT ;

CHAMARET, S ;

GRUEST, J ;

DAUGUET, C ;

AXLERBLIN, C ;

VEZINETBRUN, F ;

ROUZIOUX, C ;

ROZENBAUM, W ;

MONTAGNIER, L .

SCIENCE, 1983, 220 (4599) :868-871

[4]

BIRON CA, 1983, J IMMUNOL, V131, P1539

[5] THE PREVENTION OF HEPATITIS-B WITH VACCINE - REPORT OF THE CENTERS-FOR-DISEASE-CONTROL MULTI-CENTER EFFICACY TRIAL AMONG HOMOSEXUAL MEN [J].

FRANCIS, DP ;

HADLER, SC ;

THOMPSON, SE ;

MAYNARD, JE ;

OSTROW, DG ;

ALTMAN, N ;

BRAFF, EH ;

OMALLEY, P ;

HAWKINS, D ;

JUDSON, FN ;

PENLEY, K ;

NYLUND, T ;

CHRISTIE, G ;

MEYERS, F ;

MOORE, JN ;

GARDNER, A ;

DOTO, IL ;

MILLER, JH ;

REYNOLDS, GH ;

MURPHY, BL ;

SCHABLE, CA ;

CLARK, BT ;

CURRAN, JW ;

REDEKER, AG .

ANNALS OF INTERNAL MEDICINE, 1982, 97 (03) :362-366

[6] FREQUENT DETECTION AND ISOLATION OF CYTOPATHIC RETROVIRUSES (HTLV-III) FROM PATIENTS WITH AIDS AND AT RISK FOR AIDS [J].

GALLO, RC ;

SALAHUDDIN, SZ ;

POPOVIC, M ;

SHEARER, GM ;

KAPLAN, M ;

HAYNES, BF ;

PALKER, TJ ;

REDFIELD, R ;

OLESKE, J ;

SAFAI, B ;

WHITE, G ;

FOSTER, P ;

MARKHAM, PD .

SCIENCE, 1984, 224 (4648) :500-503

[7]

GILLIS S, 1978, J IMMUNOL, V120, P2027

[8]

GOEDERT JJ, 1982, LANCET, V1, P412

[9] ELEVATED BETA-2-MICROGLOBULIN AND LYSOZYME LEVELS IN PATIENTS WITH ACQUIRED IMMUNE-DEFICIENCY SYNDROME [J].

GRIECO, MH ;

REDDY, MM ;

KOTHARI, HB ;

LANGE, M ;

BUIMOVICIKLEIN, E ;

WILLIAM, D .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1984, 32 (02) :174-184

[10]

KERN DE, 1981, J IMMUNOL, V127, P1323

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