CORRECTION OF NON-24-HOUR SLEEP WAKE CYCLE BY MELATONIN IN A BLIND RETARDED BOY

被引：113

作者：

PALM, L ^{[1
]}

BLENNOW, G ^{[1
]}

WETTERBERG, L ^{[1
]}

机构：

[1] KAROLINSKA INST,ST GORANS CHILDRENS HOSP,DEPT PSYCHIAT,S-11281 STOCKHOLM,SWEDEN

来源：

ANNALS OF NEUROLOGY | 1991年 / 29卷 / 03期

关键词：

D O I：

10.1002/ana.410290318

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 9-year-old, blind boy with severe mental retardation with a chronic sleep/wake disturbance had a circadian rhythm of 24.75 hours and an internal desynchronization of the endogenous rhythms. Treatment with oral melatonin given at 6 PM induced a regular sleep/wake pattern. Melatonin, in this patient, convincingly entrained the endogenous rhythm to the appropriate chronological 24-hour day.

引用

页码：336 / 339

页数：4

共 14 条

[1] SOME EFFECTS OF JET-LAG AND THEIR ALLEVIATION BY MELATONIN
ARENDT, J
ALDHOUS, M
ENGLISH, J
MARKS, V
ARENDT, JH
MARKS, M
FOLKARD, S
[J]. ERGONOMICS, 1987, 30 (09) : 1379 - 1393
[2] ARENDT J, 1988, LANCET, V1, P772
[3] FRAZER A, 1987, INTEGRATIVE PSYCHIAT, V5, P3
[4] MENDELSON WB, 1987, SLEEP RES, V16, P109
[5] BLIND MAN LIVING IN NORMAL SOCIETY HAS CIRCADIAN-RHYTHMS OF 24.9 HOURS
MILES, LEM
RAYNAL, DM
WILSON, MA
[J]. SCIENCE, 1977, 198 (4315) : 421 - 423
[6] RETINOHYPOTHALAMIC PROJECTION IN RAT
MOORE, RY
LENN, NJ
[J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1972, 146 (01) : 1 - +
[7] CIRCADIAN TIMEKEEPING IN HEALTH AND DISEASE .1. BASIC PROPERTIES OF CIRCADIAN PACEMAKERS
MOOREEDE, MC
CZEISLER, CA
RICHARDSON, GS
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1983, 309 (08) : 469 - 476
[8] 4 CONGENITALLY BLIND-CHILDREN WITH CIRCADIAN SLEEP-WAKE RHYTHM DISORDER
OKAWA, M
NANAMI, T
WADA, S
SHIMIZU, T
HISHIKAWA, Y
SASAKI, H
NAGAMINE, H
TAKAHASHI, K
[J]. SLEEP, 1987, 10 (02): : 101 - 110
[9] Reiter R.J., 1988, MELATONIN CLIN PERSP, P1
[10] SACK RL, 1988, SLEEP RES, V17, P396

← 1 2 →