DETERMINANTS OF BLASTOMERE IDENTITY IN THE EARLY C-ELEGANS EMBRYO

被引：31

作者：

BOWERMAN, B

机构：

[1] Institute of Molecular Biology, University of Oregon, Eugene, Oregon

来源：

BIOESSAYS | 1995年 / 17卷 / 05期

关键词：

D O I：

10.1002/bies.950170508

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic and molecular studies of development in Caenorhabiditis elegans have identified regulators that appear to control pattern formation in the cellularized nematode embryo. Two genes, skn-1 and pie-1, are required for specifying the different identities of two sister blastomeres in a 4-cell embryo, called P2 and EMS. The skn-1 gene encodes a DNA binding protein that may control blastomere development by regulating transcription in EMS and its descendants. ABa and ABp, the other two sisters in a 4-cell embryo, are influenced to develop differently by cell signaling events that require the two genes apx-1 and glp-1. In this review, I summarize evidence that some or all of these genes may encode embryonic determinants of blastomere identity.

引用

页码：405 / 414

页数：10

共 72 条

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