17-ESTERS AND 17,21-DIESTERS OF 9ALPHA,11BETA-DICHLOROCORTICOIDS . SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY

被引：18

作者：

SHAPIRO, E

FINCKENOR, L

PLUCHET, H

WEBER, L

ROBINSON, CH

OLIVETO, EP

HERZOG, HL

TABACHNICK, II

COLLINS, E

机构：

来源：

STEROIDS | 1967年 / 9卷 / 02期

关键词：

D O I：

10.1016/0039-128X(67)90037-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The syntheses of some 17,21-diesters of dichlorisone (9[alpha], 11[beta]-dichloro-17[alpha],21-dihydroxy-l,4-pregnadiene-3,20-dione), 16[alpha]-methyldichlorisone, and 16[beta],methyldichlorisone, and some 17-monoesters of 16[alpha]-methyl-dichlorisone are reported. Anti-inflammatory activity, as measured by a granuloma pouch technique, reached a maximum for the 17-butyrate and 17-valerate of 16[alpha]-methyldichlorisone and for the 17,21-dipropionate and 17,21-dibutyrate of 16[alpha]-methyldichlorisone.

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页码：143 / +

页数：1

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