NEUROTENSIN IN HUMAN-BRAIN - REGIONAL DISTRIBUTION AND EFFECTS OF NEUROLOGICAL ILLNESS

被引：32

作者：

EMSON, PC

HORSFIELD, PM

GOEDERT, M

ROSSOR, MN

HAWKES, CH

机构：

[1] MED SCH CAMBRIDGE, CTR MRC, NEUROCHEM PHARMACOL UNIT, CAMBRIDGE CB2 2QH, ENGLAND

[2] NATL HOSP, DEPT NEUROL, LONDON WC1N 3BG, ENGLAND

[3] IPSWICH HOSP, DEPT NEUROL, IPSWICH 1P4 5PD, ENGLAND

来源：

BRAIN RESEARCH | 1985年 / 347卷 / 02期

关键词：

D O I：

10.1016/0006-8993(85)90182-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The regional distribution of neurotensin-like immunoreactivity was investigated in normal human brain and in brains of patients who had died with neurological illness. In Huntington''s disease, neurotensin was increased in the pallidum, whilst in Parkinson''s disease no significant changes in neurotensin content were observed. Similarly no changes were found in the telencephalic neurotensin content in senile dementia of the Alzheimer type. High levels of neurotensin-like immunoreactivity were detected in lumbar cerebrospinal fluid from patients and the characterization of the immunoreactive material by high-performance liquid chromatography showed it to be indistinguishable from synthetic neurotensin.

引用

页码：239 / 244

页数：6

共 43 条

[1] SOMATOSTATIN IS INCREASED IN THE BASAL GANGLIA IN HUNTINGTON DISEASE [J].