PERMEABILITY OF THE NORMAL RAT-BRAIN, SPINAL-CORD AND DORSAL-ROOT GANGLIA MICROCIRCULATIONS TO IMMUNOGLOBULINS-G

被引：36

作者：

AZZI, G

BERNAUDIN, JF

BOUCHAUD, C

BELLON, B

FLEURYFEITH, J

机构：

[1] UNIV PARIS 12, FAC MED, HISTOPHYSIOL PROC DEF LAB, 8 RUE GEN SARRAIL, F-94010 CRETEIL, FRANCE

[2] UNIV PARIS 06, CYTOL LAB, CNRS, ERA 884, PARIS, FRANCE

[3] HOP BROUSSAIS, MORPHOL & IMMUNOPATHOL RENALE LAB,CNRS,ERA 48, INSERM,U28, F-75674 PARIS 14, FRANCE

来源：

BIOLOGY OF THE CELL | 1990年 / 68卷 / 01期

关键词：

anti-HRP IgG-brain spinal cord; blood-brain barrier; electron microscopy; rat; spinal ganglion;

D O I：

10.1016/0248-4900(90)90283-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The distribution of blood-borne immunoglobulins G (IgG) was studied in the cerebral cortex, pineal gland, spinal cord and dorsal root ganglia of normal Lewis rats using the detection of autologous anti-horseradish peroxidase (HRP) antibodies. This detection was performed by means of light and electron microscopy. This study demonstrated that, in the cerebral cortex and the spinal cord microcirculations, endothelial cells are a restrictive barrier against IgG while IgG are able to diffuse into the perivascular parenchyma of the pineal gland and spinal ganglia. © 1990.

引用

页码：31 / 36

页数：6

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