ADSORPTION OF PLASMA-PROTEINS ON ARG GLY ASP SER PEPTIDE-IMMOBILIZED POLY(VINYL ALCOHOL) AND ETHYLENE ACRYLIC-ACID COPOLYMER FILMS

被引：17

作者：

NAKAJIMA, K ^{[1
]}

HIRANO, Y ^{[1
]}

IIDA, T ^{[1
]}

NAKAJIMA, A ^{[1
]}

机构：

[1] OSAKA INST TECHNOL,DEPT APPL CHEM,5-16-1 OHMIYA,ASAHI KU,OSAKA 535,JAPAN

来源：

POLYMER JOURNAL | 1990年 / 22卷 / 11期

关键词：

Ethylene-acrylic acid copolymer; Inter facial pressure; Plasma proteins adsorption; Poly(vinyl alcohol); Surface pressure;

D O I：

10.1295/polymj.22.985

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Tetrapeptide Arg-Gly-Asp-Ser (RGDS) exhibiting cell-attachment activity was immobilized to poly(vinyl alcohol) (PVA), and to ethylene-acrylic acid copolymer (PEA) conaining 2.84 mol% acrylic acid. RGDS was also immobilized to PEA via Gly-Gly-Gly (GGG) as a spacer. Adsorption behaviors of plasma proteins, albumin and γ-globulin, on these peptide-immobilized PVA and PEA surfaces were examined in phosphate buffer solution by means of interfacial pressure. It was found that the interfacial pressures of these polymer surfaces were drastically lowered by immobilizing the peptides, RGDS and GGGRGDS. © 1990, The Society of Polymer Science, Japan. All rights reserved.

引用

页码：985 / 990

页数：6

共 6 条

[1]

HIRANO Y, 1990, UNPUB J BIOMED MATER

[2] ADSORPTION BEHAVIOR OF PLASMA-PROTEINS ON POLYAMINOACID MEMBRANE-SURFACE [J].

NAKAJIMA, A ;

HATA, Y .

POLYMER JOURNAL, 1987, 19 (05) :493-500

[3] SYNTHETIC PEPTIDE WITH CELL ATTACHMENT ACTIVITY OF FIBRONECTIN [J].

PIERSCHBACHER, M ;

HAYMAN, EG ;

RUOSLAHTI, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (05) :1224-1227

[4]

PIERSCHBACHER MD, 1984, NATURE, V309

[5]

Zisman W.A., 1964, ADV CHEM SER, P1, DOI [DOI 10.1021/BA-1964-0043.CH001, 10.1021/ba-1964-0043.ch001]

[6]

UNPUB J BIOMED MATER

← 1 →