PREPARATIVE SEPARATION OF THE DIASTEREOISOMERS OF DIOXINDOLYL-L-ALANINE AND ASSIGNMENT OF STEREOCHEMISTRY AT C-3

被引：77

作者：

LABROO, RB ^{[1
]}

COHEN, LA ^{[1
]}

机构：

[1] NIDDKD, BIOORGAN CHEM LAB, BETHESDA, MD 20892 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 16期

关键词：

D O I：

10.1021/jo00303a027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The diastereoisomers of dioxindolyl-L-alanine are obtained in a 1:1 ratio by air oxidation of oxindolyl-L-alanine. Preparative separation of the diastereoisomers is achieved by reverse-phase HPLC. Stereochemistry of the hydroxyl group at C-3 is assigned by transformation to a related pair of diastereoisomers of known stereochemistry. © 1990, American Chemical Society. All rights reserved.

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页码：4901 / 4904

页数：4

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