REDUCTION OF 1-METHYL 1,2,3,4-TETRAHYDROISOQUINOLINE LEVEL IN SUBSTANTIA-NIGRA OF THE AGED RAT

被引：20

作者：

AYALA, A ^{[1
]}

PARRADO, J ^{[1
]}

CANO, J ^{[1
]}

MACHADO, A ^{[1
]}

机构：

[1] UNIV SEVILLA, FAC FARM, DEPT BIOQUIM BROMATOL & TOXICOL, E-41012 SEVILLE, SPAIN

来源：

BRAIN RESEARCH | 1994年 / 638卷 / 1-2期

关键词：

TETRAHYDROISOQUINOLINE; 1-METHYL-TETRAHYDROISOQUINOLINE; SUBSTANTIA NIGRA; STRIATUM; AGE;

D O I：

10.1016/0006-8993(94)90667-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The compounds 1,2,3,4-tetrahydroisoquinoline (TIQ) and 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ) are endogenous in humans [18] and rats [9]. Whereas TIQ seems to have neurotoxicity, 1-MeTIQ has been described as having a protective effect. In this paper, we report the concentration of TIQ and 1-MeTIQ in two areas especially influenced by aging and Parkinson's disease, the substantia nigra (SN) and striatum (ST), of the rat at different ages. 1-MeTIQ and TIQ were detected in both structures using gas chromatography-mass spectrometry with the higher content of both being in the SN. During the aging process there is a significant decrease (50%) in 1-MeTIQ levels in the SN, but TIQ levels did not change significantly in either of the studied regions.

引用

页码：334 / 336

页数：3

共 24 条

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