CREB AS A MEMORY MODULATOR - INDUCED EXPRESSION OF A DCREB2 ACTIVATOR ISOFORM ENHANCES LONG-TERM-MEMORY IN DROSOPHILA

被引:556
作者
YIN, JCP
DELVECCHIO, M
ZHOU, H
TULLY, T
机构
关键词
D O I
10.1016/0092-8674(95)90375-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB). Here, we report an enhancement of LTM formation after induced expression of an activator isoform of dCREB2. Maximum LTM is achieved after one training session, and its formation depends on phosphorylation of the activator transgene. A model of LTM formation based on differential regulation of CREB isoforms is proposed.
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页码:107 / 115
页数:9
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