ASSIGNMENT OF A LOCUS FOR MOUSE LUNG-TUMOR SUSCEPTIBILITY TO PROXIMAL CHROMOSOME-19

被引：56

作者：

DEVEREUX, TR ^{[1
]}

WISEMAN, RW ^{[1
]}

KAPLAN, N ^{[1
]}

GARREN, S ^{[1
]}

FOLEY, JF ^{[1
]}

WHITE, CM ^{[1
]}

ANNA, C ^{[1
]}

WATSON, MA ^{[1
]}

PATEL, A ^{[1
]}

JARCHOW, S ^{[1
]}

MARONPOT, RR ^{[1
]}

ANDERSON, MW ^{[1
]}

机构：

[1] NIEHS,EXPTL BIOL PROGRAM,RES TRIANGLE PK,NC 27709

来源：

MAMMALIAN GENOME | 1994年 / 5卷 / 12期

关键词：

D O I：

10.1007/BF00292007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies have hypothesized that at least three genetic loci contribute to differences in pulmonary adenoma susceptibility between mouse strains A/J and C57BL/6J. One gene that may confer susceptibility to lung tumorigenesis is the Kras protooncogene. To identify other relevant loci involved in this polygenic trait, we determined tumor multiplicity in 56 randomly chosen N-ethyl-N-nitrosourea-treated (A/J X C57BL/6J) N1 X C57BL/6 backcross (AB6N2) progeny and correlated it with genotypes at 77 microsatellite markers spanning the genome. A correlation of lung tumor multiplicity phenotypes with genotypes of microsatellite markers on distal Chromosome (Chr) 6 in the Kras region (Pas1) was confirmed, and a new region on Chr 19 (designated Pad) was identified that also contributes to susceptibility. Linkage analysis on Chr 19 with 270 AB6N2 mice localized the region flanked by D19Mit42 and D19Mit19 that is most closely associated with lung tumor susceptibility. The Pas3 locus may be an enhancer of the susceptibility locus on Chr 6.

引用

页码：749 / 755

页数：7

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