IDENTIFICATION OF A MEMBER OF THE MAPKKK FAMILY AS A POTENTIAL MEDIATOR OF TGF-BETA SIGNAL-TRANSDUCTION

被引：1189

作者：

YAMAGUCHI, K

SHIRAKABE, T

SHIBUYA, H

IRIE, K

OISHI, I

UENO, N

TANIGUCHI, T

NISHIDA, E

MATSUMOTO, K

机构：

[1] HOKKAIDO UNIV, FAC PHARMACEUT SCI, SAPPORO, HOKKAIDO 060, JAPAN

[2] NAGOYA UNIV, FAC SCI, DEPT MOLEC BIOL, CHIKUSA KU, NAGOYA, AICHI 46401, JAPAN

[3] KYOTO UNIV, INST VIRUS RES, DEPT GENET & MOLEC BIOL, SAKYO KU, KYOTO 60601, JAPAN

[4] OSAKA UNIV, INST MOLEC & CELLULAR BIOL, SUITA, OSAKA 565, JAPAN

来源：

SCIENCE | 1995年 / 270卷 / 5244期

关键词：

D O I：

10.1126/science.270.5244.2008

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mitogen-activated protein kinase (MAPK) pathway is a conserved beta eukaryotic signaling module that converts receptor signals into various outputs. MAPK is activated through phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase (MAPKKK). A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family. TAK1 was shown to participate in regulation of transcription by transforming growth factor-beta (TGF-beta). Furthermore, kinase activity of TAK1 was stimulated in response to TGF-beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-beta superfamily members.

引用

页码：2008 / 2011

页数：4

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