MECHANISM OF ACTION OF N-ACETYLCYSTEINE IN THE PROTECTION AGAINST THE HEPATOTOXICITY OF ACETAMINOPHEN IN RATS INVIVO

被引:326
作者
LAUTERBURG, BH [1 ]
CORCORAN, GB [1 ]
MITCHELL, JR [1 ]
机构
[1] BAYLOR COLL MED,DEPT INTERNAL MED,CLIN PHARMACOL SECT,HOUSTON,TX 77030
关键词
D O I
10.1172/JCI110853
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:980 / 991
页数:12
相关论文
共 42 条
[1]   QUANTITATIVE-DETERMINATION OF GLUTATHIONE, CYSTEINE, AND N-ACETYL CYSTEINE CONJUGATES OF ACETAMINOPHEN BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY [J].
BUCKPITT, AR ;
ROLLINS, DE ;
NELSON, SD ;
FRANKLIN, RB ;
MITCHELL, JR .
ANALYTICAL BIOCHEMISTRY, 1977, 83 (01) :168-177
[2]   VARYING EFFECTS OF SULFHYDRYL NUCLEOPHILES ON ACETAMINOPHEN OXIDATION AND SULFHYDRYL ADDUCT FORMATION [J].
BUCKPITT, AR ;
ROLLINS, DE ;
MITCHELL, JR .
BIOCHEMICAL PHARMACOLOGY, 1979, 28 (19) :2941-2946
[3]  
CORCORAN GB, 1978, PHARMACOLOGIST, V20, P259
[4]  
CORCORAN GB, 1980, MOL PHARMACOL, V18, P536
[5]  
CORCORAN GB, 1982, PHARMACOLOGIST, V24, P148
[6]  
CORCORAN GB, 1980, THESIS G WASHINGTON
[7]  
EBERLE D, 1981, J BIOL CHEM, V256, P2115
[8]   TISSUE SULFHYDRYL GROUPS [J].
ELLMAN, GL .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) :70-77
[9]   CLINICAL PHARMACOKINETICS OF PARACETAMOL [J].
FORREST, JAH ;
CLEMENTS, JA ;
PRESCOTT, LF .
CLINICAL PHARMACOKINETICS, 1982, 7 (02) :93-107
[10]  
GALINSKY RE, 1981, J PHARMACOL EXP THER, V219, P14